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J Clin Invest 2009;119:1159-66

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Zhou et al., 2022) reveals markedly altered abundance and diversity of gut microbiota in patients with diabetes compared to healthy individuals, characterized by low-diversity dysbiosis and an overgrowth of opportunistic pathogens

The oral bioavailability of PF-06882961 in animals was low to moderate and increased in a dose-dependent manner, which was adequate for studying preclinical in vivo efficacy and safety of PF-06882961 delivered via the oral route in standard formulations

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Valproic acid advantages: Phenobarbital has a very long half-life, which makes down-titration challenging if excessive somnolence occurs